MolNFT v1 · #5096 · protein

Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides

1E7M · Glucose 6-phosphate 1-dehydrogenase: “Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.64). MolNFT v1 #5096 on…

PDB: 1E7M
Type: protein
Length: 485 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose 6-phosphate 1-dehydrogenase
EC: 1.1.1.49
UniProt: P11411
Ligands: CA
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucose 6-phosphate 1-dehydrogenase (EC 1.1.1.49)	protein	485	40% helix, 20% strand	P11411

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	339	0.64	0.79	30	empty
2	122	0.41	0.75	19	empty
3	91	0.38	0.76	16	empty

Compared structures

1E7M · Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from leuconostoc… · the same entry in another collection · chain A against A, TM-score 1.00
P11411 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P11411) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11411
Elsewhere: RCSB PDB 1E7M · PDBe 1E7M · UniProt P11411

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