MolNFT v1 · #50957 · protein
PHOSDUCIN/TRANSDUCIN beta-gamma complex
2TRC: “PHOSDUCIN/TRANSDUCIN beta-gamma complex”. X-ray diffraction, 1 ligand (GD), 9 pockets (best druggability 0.79). MolNFT v1 #50957 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2TRC
- Type
- protein
- Length
- 625 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transducin; Phosducin
- UniProt
- P62871, P02698, P20942
- Ligands
- GD
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Transducin | protein | 340 | 7% helix, 47% strand | P62871 |
| G | Transducin | protein | 68 | 53% helix, 0% strand | P02698 |
| P | Phosducin | protein | 217 | 41% helix, 13% strand | P20942 |
Ligands and binding sites
- GD · Gadolinium atom · metal · 5 copies · chains B, P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.79 | 0.85 | 51 | empty |
| 2 | 561 | 0.69 | 0.78 | 60 | empty |
| 3 | 312 | 0.65 | 0.81 | 40 | empty |
| 4 | 61 | 0.50 | 0.86 | 16 | empty |
| 5 | 114 | 0.50 | 0.81 | 20 | empty |
Interfaces
2 interfaces between chains.
- B–G · 2613 Ų buried · 20 hydrogen bonds · protein-protein
- B–P · 2409 Ų buried · 43 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 2TRC · PHOSDUCIN/TRANSDUCIN beta-gamma complex · the same entry in another collection · chain B against B, TM-score 1.00
- P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P20942 · AlphaFold monomer V2.0 prediction for phosducin (P20942) · a predicted model of the same protein · chain P against A, TM-score 0.92
- P02698 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain G against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62871
- Every structure of UniProt P02698
- Every structure of UniProt P20942
- Elsewhere: RCSB PDB 2TRC · PDBe 2TRC · UniProt P62871 · UniProt P02698 · UniProt P20942
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