MolNFT v1 · #50949 · protein
Tyrosine hydroxylase catalytic and tetramerization domains from rat
2TOH · Tyrosine 3-monooxygenase: “Tyrosine hydroxylase catalytic and tetramerization domains from rat”. X-ray diffraction, 3 ligands (HBI, FE, CL), 1 pocket (best druggability 0.76). MolNFT v1 #50949 on GenesisL1: 3D structure, binding…
- PDB
- 2TOH
- Type
- protein
- Length
- 336 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine 3-monooxygenase
- EC
- 1.14.16.2
- UniProt
- P04177
- Ligands
- HBI, FE, CL
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine 3-monooxygenase (EC 1.14.16.2) | protein | 336 | 51% helix, 12% strand | P04177 |
Ligands and binding sites
- HBI · 7,8-dihydrobiopterin · ligand · chains A
- FE · Fe (III) ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 578 | 0.76 | 0.83 | 58 | HBI |
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 2TOH · Tyrosine hydroxylase catalytic and tetramerization domains from rat · the same entry in another collection · chain A against A, TM-score 1.00
- P04177 · AlphaFold monomer V2.0 prediction for tyrosine 3-monooxygenase (P04177) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04177
- Elsewhere: RCSB PDB 2TOH · PDBe 2TOH · UniProt P04177
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