MolNFT v1 · #50758 · protein

Solution structure of human full-length vaccinia related kinase 1 (VRK1)

2RSV · SERINE/THREONINE-protein kinase VRK1: “Solution structure of human full-length vaccinia related kinase 1 (VRK1)”. Solution nmr, 7 pockets (best druggability 0.63). MolNFT v1 #50758 on GenesisL1: 3D structure, binding sites and…

PDB: 2RSV
Type: protein
Length: 403 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase VRK1
EC: 2.7.11.1
UniProt: Q99986
Pockets: 7 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 28% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase VRK1 (EC 2.7.11.1)	protein	403	28% helix, 11% strand	Q99986

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.63	0.80	37	empty
2	267	0.53	0.75	47	empty
3	187	0.47	0.76	24	empty
4	74	0.46	0.82	16	empty
5	131	0.45	0.77	20	empty

Compared structures

2RSV · Solution structure of human full-length vaccinia related kinase 1 (VRK1) · the same entry in another collection · chain A against A, TM-score 1.00
Q99986 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase VRK1 (Q99986) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99986
Elsewhere: RCSB PDB 2RSV · PDBe 2RSV · UniProt Q99986

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.