UniProt Q99986
Serine/threonine-protein kinase VRK1 (Q99986)
Serine/threonine-protein kinase VRK1 (UniProt Q99986), EC 2.7.11.1: 36 experimental structures on GenesisL1, 23 ligands bound, 72 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99986
- Protein
- Serine/threonine-protein kinase VRK1
- EC
- 2.7.11.1
- Experimental structures
- 36
- Predicted models
- 0
- Ligands
- 23
- Pockets
- 72 · 5 records with a druggable one
Structures
36 records of Q99986 in the MolNFT archive: 36 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KTY | Solution Structure of human Vaccinia Related Kinase-1 | solution nmr | A | — | — |
| 2KTY | Solution structure of human vaccinia related kinase-1 | solution nmr | A | — | — |
| 2KUL | Solution structure of human vaccinia related kinase 1(VRK1) | solution nmr | A | — | — |
| 2KUL | Solution structure of human vaccinia related kinase 1(VRK1) | solution nmr | A | — | — |
| 2LAV | NMR solution structure of human Vaccinia-Related Kinase 1 | solution nmr | A | — | — |
| 2LAV | NMR solution structure of human vaccinia-related kinase 1 | solution nmr | A | — | — |
| 2RSV | Solution structure of human full-length vaccinia related kinase 1 (VRK1) | solution nmr | A | — | — |
| 2RSV | Solution structure of human full-length vaccinia related kinase 1 (VRK1) | solution nmr | A | — | — |
| 3OP5 | Human vaccinia-related kinase 1 | x-ray diffraction | A, B, C, D | — | — |
| 3OP5 | Human vaccinia-related kinase 1 | x-ray diffraction | A, B, C, D | — | — |
| 5UKF | Crystal structure of the human vaccinia-related kinase 1 bound to an oxindole inhibitor | x-ray diffraction | A, B, C, D | 8E1, PO4, CL | — |
| 5UVF | Crystal structure of the human vaccinia-related kinase bound to bi- D1870 | x-ray diffraction | A, B, C, D | 7DZ, PO4, CL | — |
| 6AC9 | Crystal structure of human vaccinia-related kinase 1 (VRK1) in complex with AMP-pnp | x-ray diffraction | A, B, C, D | ANP, MG, SO4, CL | — |
| 6BP0 | Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridi inhibitor | x-ray diffraction | A, B, C, D | CL, E1D, SO4 | 14 (best 0.71) |
| 6BP0 | Crystal structure of the human vaccinia-related kinase 1 bound to (R)- 2-phenylaminopteridinone… | x-ray diffraction | A, B, C, D | CL, E1D, SO4 | — |
| 6BRU | Crystal structure of the human vaccinia-related kinase bound to a (S)- 2-phenylaminopteridinone… | x-ray diffraction | A, B, C, D | SO4, E5M | — |
| 6BTW | Crystal Structure of the Human vaccinia-related kinase bound to a phenyl-pteridi inhibitor | x-ray diffraction | A, B, C, D | CL, E8D, SO4 | 15 (best 0.71) |
| 6BTW | Crystal structure of the human vaccinia-related kinase bound to a phenyl-pteridinone inhibitor | x-ray diffraction | A, B, C, D | CL, E8D, SO4 | — |
| 6BU6 | Crystal structure of the human vaccinia-related kinase bound to a bis- difluorophenol-aminopyridine… | x-ray diffraction | A, B, C, D | E8V, CL, SO4 | — |
| 6CFM | Crystal structure of the human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor | x-ray diffraction | A, B, C, D | EA7, CL | — |
| 6CMM | Crystal structure of the human vaccinia-related kinase bound to a N,N- dipropynyl-dihydropteridine… | x-ray diffraction | A, B, C, D | F7D, SO4 | — |
| 6CNX | Crystal structure of the human vaccinia-related kinase 1 (VRK1) bound to an… | x-ray diffraction | A, B, C, D | F87, SO4, FCS | — |
| 6CQH | Crystal Structure of the Human vaccinia-related kinase bound to a… | x-ray diffraction | A, B, C, D | F8Y, SO4, CL | — |
| 6CQH | Crystal structure of the human vaccinia-related kinase bound to a N… | x-ray diffraction | A, B, C, D | F8Y, SO4, CL | — |
| 6CSW | Crystal structure of the human vaccinia-related kinase bound to a N… | x-ray diffraction | A, B, C, D | SO4, FBY, CL | — |
| 6DD4 | Crystal structure of the human vaccinia-related kinase bound to a N,N- dipropyl-dihydropteridine… | x-ray diffraction | A, B, C, D | CL, G6J, SO4 | — |
| 6NPN | Crystal Structure of the Human vaccinia-related kinase bound to a… | x-ray diffraction | A, B, C, D | KWJ, SO4 | 14 (best 0.72) |
| 6NPN | Crystal structure of the human vaccinia-related kinase bound to a N,N… | x-ray diffraction | A, B, C, D | KWJ, SO4 | — |
| 6VXU | Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471 | x-ray diffraction | A, B, C, D | RTJ, SO4, VBD | 12 (best 0.70) |
| 6VXU | Structure of human vaccinia-related kinase 1 (VRK1) bound to ACH471 | x-ray diffraction | A, B, C, D | RTJ, SO4, VBD | — |
| 6VZH | Structure of human vaccinia-related kinase 1 (VRK1) bound to LDSM311 | x-ray diffraction | A, B, C, D | SO4, RYA | — |
| 7M10 | PHF2 phd domain complexed with peptide from N-terminus of VRK1 | x-ray diffraction | B | — | — |
| 7TAN | Structure of VRK1 C-terminal tail bound to nucleosome core particle | electron microscopy | K, L | — | — |
| 7TAN | Structure of VRK1 C-terminal tail bound to nucleosome core particle | electron microscopy | K, L | — | — |
| 8V42 | Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400 | x-ray diffraction | A, B, C, D | YD9, SO4 | 17 (best 0.70) |
| Q99986 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase VRK1 (Q99986) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 19 records
- CL · Chloride ion · in 13 records
- E1D · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one · in 2 records
- E8D · 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5H)-one · in 2 records
- F8Y · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- KWJ · (7R)-7-methyl-2-[(3-oxo-2,3-dihydro-1H-indazol-6-yl) amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- PO4 · Phosphate ion · in 2 records
- RTJ · (7R)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- VBD · (7S)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- 7DZ · (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- 8E1 · 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- E5M · (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one · in 1 record
- E8V · 4,4'-(2-aminopyridine-3,5-diyl)bis(2,6-difluorophenol) · in 1 record
- EA7 · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- F7D · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- F87 · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- FBY · (7R)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7, 8-dimethyl-7,8-dihydropteridin-6(5H)-one · in 1 record
- FCS · (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- G6J · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5H)-one · in 1 record
- MG · Magnesium ion · in 1 record
- RYA · (7~{R})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{H}-pteridin-6-one · in 1 record
- YD9 · (7S)-2-(3,5-difluoro-4-hydroxyanilino)-7-methyl-5-[(1,2-oxazol-5-yl)methyl]-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
Elsewhere
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