Ligand · 7DZ
7DZ · (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one
7DZ, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one (C19 H23 F2 N5 O2, 391.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site…
- Component
- 7DZ
- Formula
- C19 H23 F2 N5 O2
- Class
- ligand
- Structures
- 3
- PDB entries
- 3
Binding sites
7DZ in 3 structures; the first of them:
- 5UT1 · JAK2 JH2 in complex with bi-D1870 · 7DZ A905 · binds LEU551, LEU579, LYS581, VAL610, GLN626, GLU627, PHE628, VAL629 and 5 more
- 5UU1 · Crystal structure of human vaccinia-related kinase 2 (vrk-2) bound to bi-D1870 · 7DZ A401 · binds ILE35, GLY38, ILE43, VAL59, LYS61, GLU73, TYR77, PRO101 and 9 more
- 5UVF · Crystal structure of the human vaccinia-related kinase bound to bi- D1870 · 7DZ A401 · binds ILE43, ILE51, VAL69, GLU83, TYR87, PRO111, MET131, ASP132 and 4 more
Residues it binds most
VAL 6, ILE 5, LEU 6, LYS 5, ASP 4, GLU 5, GLY 5, ARG 5, MET 5, PHE 5 (residue and the binding sites it lines).
Found with
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