MolNFT v1 · #50710 · protein

Complex structure of the zf-cw domain and the H3K4ME3 peptide

2RR4 · Zinc finger cw-type pwwp domain protein 1: “Complex structure of the zf-cw domain and the H3K4ME3 peptide”. Solution nmr, 1 ligand (ZN). MolNFT v1 #50710 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RR4
Type: protein
Length: 79 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger cw-type pwwp domain protein 1; Histone H3
UniProt: Q9H0M4, A8K4Y7
Ligands: ZN

Structure

solution nmr · 2 distinct chains · 8% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc finger cw-type pwwp domain protein 1	protein	69	9% helix, 17% strand	Q9H0M4
B	Histone H3	protein	10	0% helix, 50% strand	A8K4Y7

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 679 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

2RR4 · Complex structure of the zf-CW domain and the H3K4me3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q9H0M4 · AlphaFold monomer V2.0 prediction for zinc finger cw-type pwwp domain protein 1 (Q9H0M4) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H0M4
Every structure of UniProt A8K4Y7
Elsewhere: RCSB PDB 2RR4 · PDBe 2RR4 · UniProt Q9H0M4 · UniProt A8K4Y7

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