MolNFT v1 · #50709 · protein
Solution structure of the complex between human vap-a msp domain and human osbp ffat motif
2RR3 · Vesicle-associated membrane protein-associated protein a: “Solution structure of the complex between human vap-a msp domain and human osbp ffat motif”. Solution nmr, 1 pocket (best druggability 0.45). MolNFT v1 #50709 on GenesisL1…
- PDB
- 2RR3
- Type
- protein
- Length
- 172 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vesicle-associated membrane protein-associated protein a; Oxysterol-binding protein 1
- UniProt
- Q9P0L0, P22059
- Pockets
- 1 · best druggability 0.45
Structure
solution nmr · 2 distinct chains · 4% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicle-associated membrane protein-associated protein a | protein | 128 | 5% helix, 43% strand | Q9P0L0 |
| B | Oxysterol-binding protein 1 | protein | 44 | 0% helix, 2% strand | P22059 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.45 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 781 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2RR3 · Solution structure of the complex between human VAP-A MSP domain and human OSBP FFAT motif · the same entry in another collection · chain A against A, TM-score 1.00
- Q9P0L0 · AlphaFold monomer V2.0 prediction for vesicle-associated membrane protein-associated… · a predicted model of the same protein · chain A against A, TM-score 0.92
- P22059 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein 1 (P22059) · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P0L0
- Every structure of UniProt P22059
- Elsewhere: RCSB PDB 2RR3 · PDBe 2RR3 · UniProt Q9P0L0 · UniProt P22059
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