MolNFT v1 · #50621 · protein

NMR solution structures of human KAP1 phd finger-bromodomain

2RO1 · Transcription intermediary factor 1-beta: “NMR solution structures of human KAP1 phd finger-bromodomain”. Solution nmr, 1 ligand (ZN), 2 pockets (best druggability 0.36). MolNFT v1 #50621 on GenesisL1: 3D structure, binding sites…

PDB: 2RO1
Type: protein
Length: 189 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription intermediary factor 1-beta
UniProt: Q13263
Ligands: ZN
Pockets: 2 · best druggability 0.36

Structure

solution nmr · 1 distinct chain · 34% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription intermediary factor 1-beta	protein	189	34% helix, 1% strand	Q13263

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	95	0.36	0.75	18	empty
2	67	0.27	0.73	15	empty

Compared structures

2RO1 · NMR Solution Structures of Human KAP1 PHD finger-bromodomain · the same entry in another collection · chain A against A, TM-score 1.00
Q13263 · AlphaFold monomer V2.0 prediction for transcription intermediary factor 1-beta (Q13263) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13263
Elsewhere: RCSB PDB 2RO1 · PDBe 2RO1 · UniProt Q13263

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