MolNFT v1 · #50618 · protein

Complex structures of cbp bromodomain with H4 ACK20 peptide

2RNY · Creb-binding protein: “Complex structures of cbp bromodomain with H4 ACK20 peptide”. Solution nmr. MolNFT v1 #50618 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RNY
Type: protein
Length: 136 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Creb-binding protein; Histone H4
EC: 2.3.1.48
UniProt: Q92793, P62805

Structure

solution nmr · 2 distinct chains · 59% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Creb-binding protein (EC 2.3.1.48)	protein	121	66% helix, 0% strand	Q92793
B	Histone H4	protein	15	0% helix, 0% strand	P62805

Interfaces

1 interface between chains.

A–B · 459 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

2RNY · Complex Structures of CBP Bromodomain with H4 ack20 Peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92793
Every structure of UniProt P62805
Elsewhere: RCSB PDB 2RNY · PDBe 2RNY · UniProt Q92793 · UniProt P62805

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