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MolNFT v1 · #50617 · protein

The structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co- activators pcaf and cbp

2RNX · Histone acetyltransferase pcaf: “The structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human…”. Solution nmr. MolNFT v1 #50617 on GenesisL1: 3D structure, binding sites and pockets…

PDB
2RNX
Type
protein
Length
131 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Histone acetyltransferase pcaf; Histone H3
EC
2.3.1.48
UniProt
Q92831, P61830

Structure

solution nmr · 2 distinct chains · 53% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AHistone acetyltransferase pcaf (EC 2.3.1.48)protein11859% helix, 0% strandQ92831
BHistone H3protein130% helix, 0% strandP61830

Interfaces

1 interface between chains.

  • A–B · 685 Ų buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

  • 2RNX · The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q92831 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT2B (Q92831) · a predicted model of the same protein · chain A against A, TM-score 0.83
  • P61830 · AlphaFold monomer V2.0 prediction for histone H3 (P61830) · a predicted model of the same protein · chain B against A, TM-score 0.30

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