MolNFT v1 · #50616 · protein
The structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co- activators pcaf and cbp
2RNW · Histone acetyltransferase pcaf: “The structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human…”. Solution nmr. MolNFT v1 #50616 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2RNW
- Type
- protein
- Length
- 133 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase pcaf; Histone H3
- EC
- 2.3.1.48
- UniProt
- Q92831, P61830
Structure
solution nmr · 2 distinct chains · 50% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase pcaf (EC 2.3.1.48) | protein | 118 | 57% helix, 0% strand | Q92831 |
| B | Histone H3 | protein | 15 | 0% helix, 0% strand | P61830 |
Interfaces
1 interface between chains.
- A–B · 674 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 2RNW · The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92831 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT2B (Q92831) · a predicted model of the same protein · chain A against A, TM-score 0.83
- P61830 · AlphaFold monomer V2.0 prediction for histone H3 (P61830) · a predicted model of the same protein · chain B against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92831
- Every structure of UniProt P61830
- Elsewhere: RCSB PDB 2RNW · PDBe 2RNW · UniProt Q92831 · UniProt P61830
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