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MolNFT v1 · #50589 · protein

Solution structure of the shp-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A

2RMX · Tyrosine-protein phosphatase non-receptor type 6: “Solution structure of the shp-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from…”. Solution nmr. MolNFT v1 #50589 on GenesisL1: 3D structure, binding…

PDB
2RMX
Type
protein
Length
133 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Tyrosine-protein phosphatase non-receptor type 6; NKG2-A/NKG2-B type II integral membrane…
EC
3.1.3.48
UniProt
P29350, P26715

Structure

solution nmr · 2 distinct chains · 16% helix, 27% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ATyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)protein11818% helix, 31% strandP29350
BNKG2-A/NKG2-B type II integral membrane proteinprotein150% helix, 0% strandP26715

Interfaces

1 interface between chains.

  • A–B · 591 Ų buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

  • 2RMX · Solution structure of the SHP-1 C-terminal SH2 domain complexed with a… · the same entry in another collection · chain A against A, TM-score 1.00
  • P29350 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6… · a predicted model of the same protein · chain A against A, TM-score 0.86
  • P26715 · AlphaFold monomer V2.0 prediction for NKG2-A/NKG2-B type II integral membrane protein… · a predicted model of the same protein · chain B against A, TM-score 0.26

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