MolNFT v1 · #50495 · protein

Crystal structure of the headpiece domain of chicken villin, P61 space group

2RJX · Villin-1: “Crystal structure of the headpiece domain of chicken villin, P61 space group”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #50495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RJX
Type: protein
Length: 131 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Villin-1
UniProt: P02640
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Villin-1	protein	67	58% helix, 0% strand	P02640
B	Villin-1	protein	64	56% helix, 0% strand	P02640

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.43	0.83	17	empty

Interfaces

1 interface between chains.

A–B · 506 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2RJX · Crystal structure of the headpiece domain of chicken villin, P61 space group · the same entry in another collection · chain A against A, TM-score 1.00
P02640 · AlphaFold monomer V2.0 prediction for villin-1 (P02640) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02640
Elsewhere: RCSB PDB 2RJX · PDBe 2RJX · UniProt P02640

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