MolNFT v1 · #50461 · protein
The reactive loop cleaved human thyroxine binding globulin complexed with thyroxine
2RIW · Thyroxine-binding globulin: “The reactive loop cleaved human thyroxine binding globulin complexed with thyroxine”. X-ray diffraction, 1 ligand (T44), 4 pockets (best druggability 0.60). MolNFT v1 #50461 on GenesisL1: 3D structure…
- PDB
- 2RIW
- Type
- protein
- Length
- 371 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thyroxine-binding globulin
- UniProt
- P05543
- Ligands
- T44
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroxine-binding globulin | protein | 337 | 34% helix, 38% strand | P05543 |
| B | Thyroxine-binding globulin | protein | 34 | 0% helix, 56% strand | P05543 |
Ligands and binding sites
- T44 · 3,5,3',5'-tetraiodo-L-thyronine · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.60 | 0.82 | 17 | T44 |
| 2 | 112 | 0.40 | 0.76 | 17 | empty |
| 3 | 55 | 0.35 | 0.78 | 12 | empty |
| 4 | 53 | 0.27 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2555 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 2RIW · The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine · the same entry in another collection · chain B against B, TM-score 1.00
- P05543 · AlphaFold monomer V2.0 prediction for thyroxine-binding globulin (P05543) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05543
- Elsewhere: RCSB PDB 2RIW · PDBe 2RIW · UniProt P05543
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.