MolNFT v1 · #50378 · protein

Crystal structure of flavin-containing monooxygenase phzs

2RGJ: “Crystal structure of flavin-containing monooxygenase phzs”. X-ray diffraction, 1 ligand (FAD), 2 pockets (best druggability 0.79). MolNFT v1 #50378 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RGJ
Type: protein
Length: 376 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flavin-containing monooxygenase
EC: 1.14.13.-
UniProt: Q9HWG9
Ligands: FAD
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Flavin-containing monooxygenase (EC 1.14.13.-)	protein	376	35% helix, 29% strand	Q9HWG9

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	881	0.79	0.82	80	FAD
2	57	0.43	0.83	18	empty

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

2RGJ · Crystal structure of flavin-containing monooxygenase PhzS · the same entry in another collection · chain A against A, TM-score 1.00
Q9HWG9 · AlphaFold monomer V2.0 prediction for 5-methylphenazine-1-carboxylate 1-monooxygenase… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HWG9
Elsewhere: RCSB PDB 2RGJ · PDBe 2RGJ · UniProt Q9HWG9

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