MolNFT v1 · #50290 · protein

Crystal structure of human glycolate oxidase in complex with sulfate

2RDW · Hydroxyacid oxidase 1: “Crystal structure of human glycolate oxidase in complex with sulfate”. X-ray diffraction, 2 ligands (FMN, SO4), 3 pockets (best druggability 0.82). MolNFT v1 #50290 on GenesisL1: 3D structure, binding sites…

PDB: 2RDW
Type: protein
Length: 359 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hydroxyacid oxidase 1
EC: 1.1.3.15
UniProt: Q9UJM8
Ligands: FMN, SO4
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hydroxyacid oxidase 1 (EC 1.1.3.15)	protein	359	44% helix, 13% strand	Q9UJM8

Ligands and binding sites

FMN · Flavin mononucleotide · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	184	0.82	0.97	31	SO4, FMN
2	115	0.42	0.76	18	empty
3	63	0.33	0.76	13	empty

Compared structures

2RDW · Crystal Structure of Human Glycolate Oxidase in Complex with Sulfate · the same entry in another collection · chain A against A, TM-score 1.00
Q9UJM8 · AlphaFold monomer V2.0 prediction for hydroxyacid oxidase 1 (Q9UJM8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UJM8
Elsewhere: RCSB PDB 2RDW · PDBe 2RDW · UniProt Q9UJM8

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