MolNFT v1 · #50258 · protein
Structure of a human P110ALPHA/P85ALPHA complex
2RD0 · Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic…: “Structure of a human P110ALPHA/P85ALPHA complex”. X-ray diffraction, 14 pockets (best druggability 0.87). MolNFT v1 #50258 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2RD0
- Type
- protein
- Length
- 1,136 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform…
- EC
- 2.7.1.153
- UniProt
- P42336, P27986
- Pockets
- 14 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) | protein | 997 | 38% helix, 16% strand | P42336 |
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 139 | 74% helix, 0% strand | P27986 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1103 | 0.87 | 0.88 | 97 | empty |
| 2 | 1048 | 0.85 | 0.86 | 121 | empty |
| 3 | 554 | 0.78 | 0.84 | 56 | empty |
| 4 | 333 | 0.62 | 0.78 | 28 | empty |
| 5 | 133 | 0.57 | 0.83 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1875 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 2RD0 · PDBe 2RD0 · UniProt P42336 · UniProt P27986
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