MolNFT v1 · #50232 · protein
Crystal structure of the NR3A ligand binding core complex with glycine at 1.58 ångström resolution
2RC7 · Glutamate [NMDA] receptor subunit 3A: “Crystal structure of the NR3A ligand binding core complex with glycine at 1.58 ångström resolution”. X-ray diffraction, 3 ligands (GLY, CL, BR), 1 pocket (best druggability 0.81). MolNFT v1…
- PDB
- 2RC7
- Type
- protein
- Length
- 568 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate [NMDA] receptor subunit 3A
- UniProt
- Q9R1M7
- Ligands
- GLY, CL, BR
- Pockets
- 1 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamate [NMDA] receptor subunit 3A | protein | 284 | 36% helix, 24% strand | Q9R1M7 |
Ligands and binding sites
- GLY · Glycine · ligand · 2 copies · chains A, B
- CL · Chloride ion · ion · 7 copies · chains A, B
- BR · Bromide ion · ion · chains A
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 933 | 0.81 | 0.83 | 85 | CL |
Interfaces
1 interface between chains.
- A–B · 761 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2RC7 · Crystal structure of the NR3A ligand binding core complex with glycine at 1.58 Angstrom… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9R1M7 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 3A (Q9R1M7) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9R1M7
- Elsewhere: RCSB PDB 2RC7 · PDBe 2RC7 · UniProt Q9R1M7
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