MolNFT v1 · #50229 · protein
Crystal structure of the hat domain of the human moz protein
2RC4 · Histone acetyltransferase MYST3: “Crystal structure of the hat domain of the human moz protein”. X-ray diffraction, 2 ligands (ACO, ZN), 4 pockets (best druggability 0.69). MolNFT v1 #50229 on GenesisL1: 3D structure, binding sites…
- PDB
- 2RC4
- Type
- protein
- Length
- 264 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase MYST3
- EC
- 2.3.1.48, 2.3.1.-
- UniProt
- Q92794
- Ligands
- ACO, ZN
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase MYST3 (EC 2.3.1.48, 2.3.1.-) | protein | 264 | 31% helix, 19% strand | Q92794 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 390 | 0.69 | 0.81 | 53 | ACO |
| 2 | 153 | 0.62 | 0.84 | 23 | empty |
| 3 | 123 | 0.41 | 0.75 | 22 | empty |
| 4 | 79 | 0.40 | 0.78 | 19 | empty |
Compared structures
- 2RC4 · Crystal Structure of the HAT domain of the human MOZ protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q92794 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT6A (Q92794) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92794
- Elsewhere: RCSB PDB 2RC4 · PDBe 2RC4 · UniProt Q92794
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