MolNFT v1 · #50147 · protein
Shaker family voltage dependent potassium channel (KV1.2-KV2.1 paddle chimera channel) in association with beta subunit
2R9R · Voltage-gated potassium channel subunit beta-2: “Shaker family voltage dependent potassium channel (KV1.2-KV2.1 paddle chimera channel) in association with…”. X-ray diffraction, 3 ligands (PGW, NAP, K), 13 pockets (best druggability…
- PDB
- 2R9R
- Type
- protein
- Length
- 1,401 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2; Paddle chimera voltage gated potassium…
- UniProt
- P62483
- Ligands
- PGW, NAP, K
- Pockets
- 13 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Voltage-gated potassium channel subunit beta-2 | protein | 326 | 51% helix, 16% strand | P62483 |
| B | Paddle chimera voltage gated potassium channel KV1.2-KV2.1 | protein | 386 | 61% helix, 5% strand | — |
| H | Paddle chimera voltage gated potassium channel KV1.2-KV2.1 | protein | 363 | 65% helix, 5% strand | — |
Ligands and binding sites
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 17 copies · chains B, H
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, G
- K · Potassium ion · metal · 8 copies · chains B, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.72 | 0.87 | 37 | NAP |
| 2 | 314 | 0.71 | 0.84 | 58 | NAP |
| 3 | 188 | 0.51 | 0.77 | 28 | empty |
| 4 | 86 | 0.41 | 0.78 | 20 | empty |
| 5 | 60 | 0.39 | 0.80 | 16 | empty |
Interfaces
2 interfaces between chains.
- G–H · 414 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 411 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2R9R · Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in… · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Elsewhere: RCSB PDB 2R9R · PDBe 2R9R · UniProt P62483
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