MolNFT v1 · #50080 · protein

Crystal structure of VP1 apoenzyme of rotavirus SA11 (C-terminal hexahistidine-tagged)

2R7Q · RNA-dependent RNA polymerase: “Crystal structure of VP1 apoenzyme of rotavirus SA11 (C-terminal hexahistidine-tagged)”. X-ray diffraction, 14 pockets (best druggability 0.77). MolNFT v1 #50080 on GenesisL1: 3D structure, binding…

PDB: 2R7Q
Type: protein
Length: 1,072 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase
UniProt: O37061
Pockets: 14 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase	protein	1072	54% helix, 12% strand	O37061

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	734	0.77	0.82	77	empty
2	271	0.73	0.87	40	empty
3	379	0.66	0.79	32	empty
4	295	0.64	0.81	41	empty
5	148	0.60	0.84	26	empty

Compared structures

2R7Q · Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O37061
Elsewhere: RCSB PDB 2R7Q · PDBe 2R7Q · UniProt O37061

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