MolNFT v1 · #49988 · protein
Crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
2R52 · Bone morphogenetic protein 6: “Crystal structure analysis of bone morphogenetic protein-6 (bmp-6)”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #49988 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2R52
- Type
- protein
- Length
- 210 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone morphogenetic protein 6
- UniProt
- P22004
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bone morphogenetic protein 6 | protein | 105 | 13% helix, 46% strand | P22004 |
Ligands and binding sites
- IPA · Isopropyl alcohol · additive · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.39 | 0.76 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 1242 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 2R52 · Crystal structure analysis of Bone Morphogenetic Protein-6 (BMP-6) · the same entry in another collection · chain A against A, TM-score 1.00
- P22004 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 6 (P22004) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22004
- Elsewhere: RCSB PDB 2R52 · PDBe 2R52 · UniProt P22004
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.