MolNFT v1 · #49915 · protein
Urokinase plasminogen activator B-chain-gppe complex
2R2W · Plasminogen activator, urokinase: “Urokinase plasminogen activator B-chain-gppe complex”. X-ray diffraction, 2 ligands (4PG, SO4), 1 pocket (best druggability 0.43). MolNFT v1 #49915 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2R2W
- Type
- protein
- Length
- 247 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator, urokinase
- EC
- 3.4.21.73
- UniProt
- Q5SWW9
- Ligands
- 4PG, SO4
- Pockets
- 1 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| U | Plasminogen activator, urokinase (EC 3.4.21.73) | protein | 247 | 11% helix, 39% strand | Q5SWW9 |
Ligands and binding sites
- 4PG · 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine · ligand · chains U
- SO4 · Sulfate ion · ion · chains U
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.43 | 0.77 | 32 | 4PG |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2R2W · Urokinase plasminogen activator B-chain-GPPE complex · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SWW9
- Elsewhere: RCSB PDB 2R2W · PDBe 2R2W · UniProt Q5SWW9
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