Research workbench

Urokinase plasminogen activator B-chain-gppe complex

Analyse Urokinase plasminogen activator B-chain-gppe complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2R2W
Type: protein
Length: 247 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasminogen activator, urokinase
EC: 3.4.21.73
UniProt: Q5SWW9
Ligands: 4PG, SO4
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Plasminogen activator, urokinase (EC 3.4.21.73)	protein	247	11% helix, 39% strand	Q5SWW9

Ligands and binding sites

4PG · 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine · ligand · chains U
SO4 · Sulfate ion · ion · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.43	0.77	32	4PG

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2R2W · Urokinase plasminogen activator B-chain-GPPE complex · the same entry in another collection · chain U against U, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SWW9
Elsewhere: RCSB PDB 2R2W · PDBe 2R2W · UniProt Q5SWW9

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