MolNFT v1 · #49855 · protein

Crystal structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert)

2R16 · Neurexin-1-alpha: “Crystal structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert)”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.50). MolNFT v1 #49855 on GenesisL1: 3D structure, binding…

PDB: 2R16
Type: protein
Length: 175 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurexin-1-alpha
UniProt: Q28146
Ligands: CA
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurexin-1-alpha	protein	175	4% helix, 54% strand	Q28146

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.50	0.85	23	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2R16 · Crystal Structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert) · the same entry in another collection · chain A against A, TM-score 1.00
Q28146 · AlphaFold monomer V2.0 prediction for neurexin-1 (Q28146) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q28146
Elsewhere: RCSB PDB 2R16 · PDBe 2R16 · UniProt Q28146

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