MolNFT v1 · #49845 · protein

Structure of the RSC4 tandem bromodomain acetylated at K25

2R0V · Chromatin structure-remodeling complex protein RSC4: “Structure of the RSC4 tandem bromodomain acetylated at K25”. X-ray diffraction, 1 ligand (SO4), 9 pockets (best druggability 0.79). MolNFT v1 #49845 on GenesisL1: 3D structure…

PDB: 2R0V
Type: protein
Length: 870 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromatin structure-remodeling complex protein RSC4
UniProt: Q02206
Ligands: SO4
Pockets: 9 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 58% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromatin structure-remodeling complex protein RSC4	protein	293	59% helix, 2% strand	Q02206
B	Chromatin structure-remodeling complex protein RSC4	protein	286	58% helix, 2% strand	Q02206
C	Chromatin structure-remodeling complex protein RSC4	protein	291	58% helix, 2% strand	Q02206

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1010	0.79	0.80	73	empty
2	386	0.76	0.85	38	empty
3	440	0.72	0.82	35	SO4
4	416	0.70	0.81	36	empty
5	342	0.60	0.77	41	empty

Interfaces

3 interfaces between chains.

B–C · 778 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 374 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 163 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified (acetylation).

Compared structures

2R0V · Structure of the Rsc4 tandem bromodomain acetylated at K25 · the same entry in another collection · chain A against A, TM-score 1.00
Q02206 · AlphaFold monomer V2.0 prediction for chromatin structure-remodeling complex subunit RSC4… · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02206
Elsewhere: RCSB PDB 2R0V · PDBe 2R0V · UniProt Q02206

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