Research workbench
Structure of the RSC4 tandem bromodomain acetylated at K25
Analyse Structure of the RSC4 tandem bromodomain acetylated at K25 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R0V
- Type
- protein
- Length
- 870 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin structure-remodeling complex protein RSC4
- UniProt
- Q02206
- Ligands
- SO4
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin structure-remodeling complex protein RSC4 | protein | 293 | 59% helix, 2% strand | Q02206 |
| B | Chromatin structure-remodeling complex protein RSC4 | protein | 286 | 58% helix, 2% strand | Q02206 |
| C | Chromatin structure-remodeling complex protein RSC4 | protein | 291 | 58% helix, 2% strand | Q02206 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1010 | 0.79 | 0.80 | 73 | empty |
| 2 | 386 | 0.76 | 0.85 | 38 | empty |
| 3 | 440 | 0.72 | 0.82 | 35 | SO4 |
| 4 | 416 | 0.70 | 0.81 | 36 | empty |
| 5 | 342 | 0.60 | 0.77 | 41 | empty |
Interfaces
3 interfaces between chains.
- B–C · 778 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 374 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 163 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (acetylation).
Compared structures
- 2R0V · Structure of the Rsc4 tandem bromodomain acetylated at K25 · the same entry in another collection · chain A against A, TM-score 1.00
- Q02206 · AlphaFold monomer V2.0 prediction for chromatin structure-remodeling complex subunit RSC4… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02206
- Elsewhere: RCSB PDB 2R0V · PDBe 2R0V · UniProt Q02206
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.