MolNFT v1 · #49051 · protein
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase bound to ump
2QCD · Uridine 5'-monophosphate synthase (ump synthase): “Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase bound to ump”. X-ray diffraction, 1 ligand (U5P), 2 pockets (best druggability 0.76).…
- PDB
- 2QCD
- Type
- protein
- Length
- 516 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridine 5'-monophosphate synthase (ump synthase)
- EC
- 4.1.1.23
- UniProt
- P11172
- Ligands
- U5P
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Uridine 5'-monophosphate synthase (ump synthase) (EC 4.1.1.23) | protein | 258 | 44% helix, 17% strand | P11172 |
Ligands and binding sites
- U5P · Uridine-5'-monophosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.76 | 0.96 | 30 | U5P |
| 2 | 121 | 0.73 | 0.93 | 32 | U5P |
Interfaces
1 interface between chains.
- A–B · 1939 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 2QCD · Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP… · the same entry in another collection · chain A against A, TM-score 1.00
- P11172 · AlphaFold monomer V2.0 prediction for uridine 5'-monophosphate synthase (P11172) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11172
- Elsewhere: RCSB PDB 2QCD · PDBe 2QCD · UniProt P11172
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