MolNFT v1 · #48999 · protein
Crystal structure of huntingtin-interacting protein 1 (HIP1) coiled-coil domain with a basic surface suitable for hip-protein interactor (hippi)
2QA7: “Crystal structure of huntingtin-interacting protein 1 (HIP1) coiled-coil domain with a basic surface suitable…”. X-ray diffraction, 1 pocket (best druggability 0.26). MolNFT v1 #48999 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2QA7
- Type
- protein
- Length
- 341 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Huntingtin-interacting protein 1
- UniProt
- O00291
- Pockets
- 1 · best druggability 0.26
Structure
x-ray diffraction · 3 distinct chains · 94% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Huntingtin-interacting protein 1 | protein | 99 | 92% helix, 0% strand | O00291 |
| B, D | Huntingtin-interacting protein 1 | protein | 70 | 96% helix, 0% strand | O00291 |
| C | Huntingtin-interacting protein 1 | protein | 102 | 94% helix, 0% strand | O00291 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.26 | 0.73 | 16 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1946 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1912 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 368 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 199 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2QA7 · Crystal structure of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain with a… · the same entry in another collection · chain A against A, TM-score 1.00
- O00291 · AlphaFold monomer V2.0 prediction for huntingtin-interacting protein 1 (O00291) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00291
- Elsewhere: RCSB PDB 2QA7 · PDBe 2QA7 · UniProt O00291
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