MolNFT v1 · #48969 · protein

Structure of FTSY:GMPPNP with mgcl complex

2Q9C · Cell division protein ftsy: “Structure of FTSY:GMPPNP with mgcl complex”. X-ray diffraction, 2 ligands (GNP, SO4), 10 pockets (best druggability 0.75). MolNFT v1 #48969 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Q9C
Type: protein
Length: 594 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein ftsy
UniProt: P83749
Ligands: GNP, SO4
Pockets: 10 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division protein ftsy	protein	304	50% helix, 12% strand	P83749
B	Cell division protein ftsy	protein	290	49% helix, 12% strand	P83749

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
SO4 · Sulfate ion · ion · 8 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	487	0.75	0.84	49	SO4
2	494	0.70	0.80	57	SO4
3	280	0.62	0.80	42	GNP
4	125	0.57	0.84	18	empty
5	199	0.50	0.76	31	SO4

Interfaces

1 interface between chains.

A–B · 1189 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2Q9C · Structure of FTSY:GMPPNP with MGCL Complex · the same entry in another collection · chain A against A, TM-score 1.00
P83749 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor ftsy (P83749) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83749
Elsewhere: RCSB PDB 2Q9C · PDBe 2Q9C · UniProt P83749

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