MolNFT v1 · #48952 · protein
Crystal structure of MRE11 from thermotoga maritima MSB8 (TM1635) at 2.20 a resolution
2Q8U · Exonuclease, putative: “Crystal structure of MRE11 from thermotoga maritima MSB8 (TM1635) at 2.20 a resolution”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #48952 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2Q8U
- Type
- protein
- Length
- 602 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Exonuclease, putative
- UniProt
- Q9X1X0
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Exonuclease, putative | protein | 308 | 28% helix, 31% strand | Q9X1X0 |
| B | Exonuclease, putative | protein | 294 | 28% helix, 30% strand | Q9X1X0 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.69 | 0.84 | 35 | empty |
| 2 | 236 | 0.61 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 800 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 2Q8U · Crystal structure of MRE11 from thermotoga maritima MSB8 (TM1635) at 2.20 a resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X1X0
- Elsewhere: RCSB PDB 2Q8U · PDBe 2Q8U · UniProt Q9X1X0
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