MolNFT v1 · #48570 · protein

Crystal structure of the murray valley encephalitis virus NS5 2'-O methyltransferase domain in complex with SAM and gtpa

2PXC · Genome polyprotein [contains: capsid protein C (core…: “Crystal structure of the murray valley encephalitis virus NS5 2'-O methyltransferase domain in complex with…”. X-ray diffraction, 2 ligands (G3A, SAM), 1 pocket (best…

PDB: 2PXC
Type: protein
Length: 263 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein [contains: capsid protein C (core protein)
EC: 2.7.7.48
UniProt: P05769
Ligands: G3A, SAM
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein [contains: capsid protein C (core protein) (EC 2.7.7.48)	protein	263	37% helix, 16% strand	P05769

Ligands and binding sites

G3A · Guanosine-P3-adenosine-5',5'-triphosphate · ligand · 2 copies · chains A
SAM · S-adenosylmethionine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.68	0.80	47	SAM

Compared structures

2PXC · Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05769
Elsewhere: RCSB PDB 2PXC · PDBe 2PXC · UniProt P05769

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