MolNFT v1 · #48553 · protein

TRNA guanine transglycosylase E235Q mutant in complex with PREQ0

2PWV · Queuine tRNA-ribosyltransferase: “TRNA guanine transglycosylase E235Q mutant in complex with PREQ0”. X-ray diffraction, 2 ligands (PQ0, ZN), 1 pocket (best druggability 0.59). MolNFT v1 #48553 on GenesisL1: 3D structure, binding…

PDB: 2PWV
Type: protein
Length: 361 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: PQ0, ZN
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	361	47% helix, 17% strand	P28720

Ligands and binding sites

PQ0 · 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	231	0.59	0.80	37	PQ0, GOL

Compared structures

2PWV · tRNA guanine transglycosylase E235Q mutant in complex with preQ0 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 2PWV · PDBe 2PWV · UniProt P28720

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