MolNFT v1 · #48516 · protein
Crystal structure of the catalytic subunit of protein kinase CK2 (C- terminal deletion mutant 1-335) in complex with two sulfate ions
2PVR · Casein kinase II subunit alpha, catalytic subunit: “Crystal structure of the catalytic subunit of protein kinase CK2 (C- terminal deletion mutant 1-335) in…”. X-ray diffraction, 2 ligands (ANP, SO4), 3 pockets (best druggability…
- PDB
- 2PVR
- Type
- protein
- Length
- 328 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II subunit alpha, catalytic subunit
- EC
- 2.7.11.1
- UniProt
- P68400
- Ligands
- ANP, SO4
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase II subunit alpha, catalytic subunit (EC 2.7.11.1) | protein | 328 | 41% helix, 15% strand | P68400 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.68 | 0.80 | 43 | ANP |
| 2 | 62 | 0.44 | 0.82 | 18 | empty |
| 3 | 54 | 0.28 | 0.75 | 13 | empty |
Compared structures
- 2PVR · Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion… · the same entry in another collection · chain A against A, TM-score 1.00
- P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68400
- Elsewhere: RCSB PDB 2PVR · PDBe 2PVR · UniProt P68400
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.