MolNFT v1 · #48504 · protein
Crystal structure of tyrosine phosphorylated activated FGF receptor 2 (FGFR2) kinase domain in complex with ATP analog and substrate peptide
2PVF · Fibroblast growth factor receptor 2: “Crystal structure of tyrosine phosphorylated activated FGF receptor 2 (FGFR2) kinase domain in complex with…”. X-ray diffraction, 2 ligands (ACP, MG), 1 pocket (best druggability 0.70). MolNFT…
- PDB
- 2PVF
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 2
- EC
- 2.7.10.1
- UniProt
- P21802
- Ligands
- ACP, MG
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 288 | 39% helix, 17% strand | P21802 |
| B | Fibroblast growth factor receptor 2 | protein | 4 | 0% helix, 0% strand | P21802 |
Ligands and binding sites
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 540 | 0.70 | 0.79 | 47 | MG, ACP |
Interfaces
1 interface between chains.
- A–B · 328 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 2PVF · Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21802
- Elsewhere: RCSB PDB 2PVF · PDBe 2PVF · UniProt P21802
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