MolNFT v1 · #48450 · protein
Structure of nk cell receptor 2B4 (CD244)
2PTU · Natural killer cell receptor 2B4: “Structure of nk cell receptor 2B4 (CD244)”. X-ray diffraction, 5 pockets (best druggability 0.35). MolNFT v1 #48450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2PTU
- Type
- protein
- Length
- 418 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Natural killer cell receptor 2B4
- UniProt
- Q07763
- Pockets
- 5 · best druggability 0.35
Structure
x-ray diffraction · 4 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Natural killer cell receptor 2B4 | protein | 106 | 7% helix, 46% strand | Q07763 |
| B | Natural killer cell receptor 2B4 | protein | 107 | 7% helix, 53% strand | Q07763 |
| C | Natural killer cell receptor 2B4 | protein | 102 | 7% helix, 51% strand | Q07763 |
| D | Natural killer cell receptor 2B4 | protein | 103 | 7% helix, 51% strand | Q07763 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.35 | 0.75 | 19 | empty |
| 2 | 56 | 0.30 | 0.76 | 14 | empty |
| 3 | 55 | 0.30 | 0.75 | 14 | empty |
| 4 | 50 | 0.30 | 0.77 | 19 | empty |
| 5 | 51 | 0.27 | 0.75 | 21 | empty |
Interfaces
3 interfaces between chains.
- B–D · 687 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 684 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 443 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07763
- Elsewhere: RCSB PDB 2PTU · PDBe 2PTU · UniProt Q07763
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