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Structure of nk cell receptor 2B4 (CD244)

Analyse Structure of nk cell receptor 2B4 (CD244) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2PTU
Type
protein
Length
418 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Natural killer cell receptor 2B4
UniProt
Q07763
Pockets
5 · best druggability 0.35

Structure

x-ray diffraction · 4 distinct chains · 7% helix, 50% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANatural killer cell receptor 2B4protein1067% helix, 46% strandQ07763
BNatural killer cell receptor 2B4protein1077% helix, 53% strandQ07763
CNatural killer cell receptor 2B4protein1027% helix, 51% strandQ07763
DNatural killer cell receptor 2B4protein1037% helix, 51% strandQ07763

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1860.350.7519empty
2560.300.7614empty
3550.300.7514empty
4500.300.7719empty
5510.270.7521empty

Interfaces

3 interfaces between chains.

  • B–D · 687 Ų buried · 19 hydrogen bonds · protein-protein
  • A–C · 684 Ų buried · 18 hydrogen bonds · protein-protein
  • C–D · 443 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 2PTU · Structure of NK cell receptor 2B4 (CD244) · the same entry in another collection · chain D against D, TM-score 1.00
  • Q07763 · AlphaFold monomer V2.0 prediction for natural killer cell receptor 2B4 (Q07763) · a predicted model of the same protein · chain D against A, TM-score 0.95

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