MolNFT v1 · #48419 · protein

Human psoriasin (S100A7) CA2+ and ZN2+ bound form (crystal form II)

2PSR: “Human psoriasin (S100A7) CA2+ and ZN2+ bound form (crystal form II)”. X-ray diffraction, 2 ligands (CA, ZN), 1 pocket (best druggability 0.26). MolNFT v1 #48419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2PSR
Type: protein
Length: 96 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Psoriasin
UniProt: P31151
Ligands: CA, ZN
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 1 distinct chain · 66% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Psoriasin	protein	96	66% helix, 4% strand	P31151

Ligands and binding sites

CA · Calcium ion · metal · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.26	0.73	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2PSR · Human psoriasin (S100A7) CA2+ and ZN2+ bound form (crystal form II) · the same entry in another collection · chain A against A, TM-score 1.00
P31151 · AlphaFold monomer V2.0 prediction for protein S100-A7 (P31151) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31151
Elsewhere: RCSB PDB 2PSR · PDBe 2PSR · UniProt P31151

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