MolNFT v1 · #48296 · protein
TRNA guanine transglycosylase (tgt) E235Q mutant in complex with guanine
2POT · Queuine tRNA-ribosyltransferase: “TRNA guanine transglycosylase (tgt) E235Q mutant in complex with guanine”. X-ray diffraction, 2 ligands (GUN, ZN), 1 pocket (best druggability 0.56). MolNFT v1 #48296 on GenesisL1: 3D structure…
- PDB
- 2POT
- Type
- protein
- Length
- 355 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase
- EC
- 2.4.2.29
- UniProt
- P28720
- Ligands
- GUN, ZN
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase (EC 2.4.2.29) | protein | 355 | 47% helix, 18% strand | P28720 |
Ligands and binding sites
- GUN · Guanine · ligand · chains A
- ZN · Zinc ion · metal · chains A
- GOL · Glycerol · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.56 | 0.81 | 28 | GUN, GOL |
Compared structures
- 2POT · tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28720
- Elsewhere: RCSB PDB 2POT · PDBe 2POT · UniProt P28720
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