MolNFT v1 · #48231 · protein
Ef-hand domain of human rasef
2PMY · RAS and ef-hand domain-containing protein: “Ef-hand domain of human rasef”. X-ray diffraction, 3 ligands (CA, UNX, SO4), 1 pocket (best druggability 0.85). MolNFT v1 #48231 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2PMY
- Type
- protein
- Length
- 145 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS and ef-hand domain-containing protein
- UniProt
- Q8IZ41
- Ligands
- CA, UNX, SO4
- Pockets
- 1 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS and ef-hand domain-containing protein | protein | 73 | 64% helix, 5% strand | Q8IZ41 |
| B | RAS and ef-hand domain-containing protein | protein | 72 | 64% helix, 6% strand | Q8IZ41 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B
- UNX · Unknown atom or ion · ion · 4 copies · chains A, B
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.85 | 0.97 | 30 | UNX |
Interfaces
1 interface between chains.
- A–B · 1161 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IZ41
- Elsewhere: RCSB PDB 2PMY · PDBe 2PMY · UniProt Q8IZ41
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