MolNFT v1 · #48161 · protein
Crystal structure of the human clp-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1
2PKT · PDZ and lim domain protein 1: “Crystal structure of the human clp-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1”. X-ray diffraction, 2 ligands (CA, CL), 1 pocket (best druggability 0.32). MolNFT v1 #48161 on…
- PDB
- 2PKT
- Type
- protein
- Length
- 91 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PDZ and lim domain protein 1
- UniProt
- O00151
- Ligands
- CA, CL
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PDZ and lim domain protein 1 | protein | 91 | 18% helix, 43% strand | O00151 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- ACT · Acetate ion · additive · chains A
- PG4 · Tetraethylene glycol · additive · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.32 | 0.76 | 13 | empty |
Compared structures
- 2PKT · Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human… · the same entry in another collection · chain A against A, TM-score 1.00
- O00151 · AlphaFold monomer V2.0 prediction for PDZ and lim domain protein 1 (O00151) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00151
- Elsewhere: RCSB PDB 2PKT · PDBe 2PKT · UniProt O00151
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