MolNFT v1 · #48150 · protein
Structure of a complex between the a subunit of protein phosphatase 2A and the small T antigen of SV40
2PKG · SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory…: “Structure of a complex between the a subunit of protein phosphatase 2A and the small T antigen of SV40”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability…
- PDB
- 2PKG
- Type
- protein
- Length
- 1,318 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory subunit a alpha isoform; Small…
- UniProt
- P30153, P03081
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory subunit a alpha isoform | protein | 579 | 72% helix, 0% strand | P30153 |
| C, D | Small T antigen | protein | 80 | 53% helix, 0% strand | P03081 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 718 | 0.75 | 0.81 | 58 | empty |
| 2 | 379 | 0.67 | 0.80 | 41 | empty |
| 3 | 261 | 0.52 | 0.75 | 33 | empty |
| 4 | 186 | 0.45 | 0.74 | 28 | empty |
| 5 | 57 | 0.26 | 0.72 | 7 | empty |
Interfaces
5 interfaces between chains.
- A–C · 531 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 530 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 488 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 416 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 342 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2PKG · Structure of a complex between the A subunit of protein phosphatase 2A and the small t… · the same entry in another collection · chain A against A, TM-score 1.00
- P30153 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 65 kda… · a predicted model of the same protein · chain B against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30153
- Every structure of UniProt P03081
- Elsewhere: RCSB PDB 2PKG · PDBe 2PKG · UniProt P30153 · UniProt P03081
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