MolNFT v1 · #47991 · protein
Crystal structure of the cytoplasmic domain of the human chloride channel clc-ka
2PFI · Chloride channel protein clc-ka: “Crystal structure of the cytoplasmic domain of the human chloride channel clc-ka”. X-ray diffraction, 2 ligands (CL, IOD), 3 pockets (best druggability 0.63). MolNFT v1 #47991 on GenesisL1: 3D…
- PDB
- 2PFI
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride channel protein clc-ka
- UniProt
- P51800
- Ligands
- CL, IOD
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride channel protein clc-ka | protein | 145 | 34% helix, 24% strand | P51800 |
| B | Chloride channel protein clc-ka | protein | 148 | 34% helix, 24% strand | P51800 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.63 | 0.84 | 33 | empty |
| 2 | 222 | 0.52 | 0.76 | 35 | empty |
| 3 | 178 | 0.49 | 0.76 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 810 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2PFI · Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka · the same entry in another collection · chain A against A, TM-score 1.00
- P51800 · AlphaFold monomer V2.0 prediction for chloride channel protein clc-ka (P51800) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51800
- Elsewhere: RCSB PDB 2PFI · PDBe 2PFI · UniProt P51800
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.