MolNFT v1 · #47961 · protein
Crystal structure of the uhm domain of human SPF45 in complex with SF3B155-ULM5
2PEH · Splicing factor 45: “Crystal structure of the uhm domain of human SPF45 in complex with SF3B155-ULM5”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #47961 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2PEH
- Type
- protein
- Length
- 227 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor 45; Splicing factor 3B subunit 1
- UniProt
- Q96I25, O75533
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Splicing factor 45 | protein | 104 | 27% helix, 28% strand | Q96I25 |
| C | Splicing factor 3B subunit 1 | protein | 10 | 0% helix, 10% strand | O75533 |
| D | Splicing factor 3B subunit 1 | protein | 9 | 0% helix, 11% strand | O75533 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.55 | 0.79 | 28 | empty |
| 2 | 175 | 0.47 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–C · 548 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 488 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 268 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2PEH · Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5 · the same entry in another collection · chain A against A, TM-score 1.00
- Q96I25 · AlphaFold monomer V2.0 prediction for splicing factor 45 (Q96I25) · a predicted model of the same protein · chain A against A, TM-score 0.96
- O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain D against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96I25
- Every structure of UniProt O75533
- Elsewhere: RCSB PDB 2PEH · PDBe 2PEH · UniProt Q96I25 · UniProt O75533
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