MolNFT v1 · #47797 · protein
E. COLI methionine aminopeptidase dimetalated with inhibitor YE6
2P9A: “E. COLI methionine aminopeptidase dimetalated with inhibitor YE6”. X-ray diffraction, 3 ligands (YE6, MN, NA), 2 pockets (best druggability 0.58). MolNFT v1 #47797 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2P9A
- Type
- protein
- Length
- 262 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionine aminopeptidase
- EC
- 3.4.11.18
- UniProt
- P0AE18
- Ligands
- YE6, MN, NA
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methionine aminopeptidase (EC 3.4.11.18) | protein | 262 | 29% helix, 28% strand | P0AE18 |
Ligands and binding sites
- YE6 · 5-(2-chlorophenyl)furan-2-carbohydrazide · ligand · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.58 | 0.83 | 27 | YE6 |
| 2 | 51 | 0.31 | 0.77 | 15 | empty |
Compared structures
- 2P9A · E. coli methionine aminopeptidase dimetalated with inhibitor YE6 · the same entry in another collection · chain A against A, TM-score 1.00
- P0AE18 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase (P0AE18) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE18
- Elsewhere: RCSB PDB 2P9A · PDBe 2P9A · UniProt P0AE18
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.