UniProt P0AE18
Methionine aminopeptidase (P0AE18)
Methionine aminopeptidase (UniProt P0AE18), EC 3.4.11.18: 57 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AE18
- Protein
- Methionine aminopeptidase
- EC
- 3.4.11.18
- Experimental structures
- 57
- Predicted models
- 1
- Pockets
- 3 · 0 records with a druggable one
Structures
58 records of P0AE18 in the MolNFT archive: 57 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EVC | Crystal structure of E. Coli. methionine amino peptidase in complex with… | x-ray diffraction | A | — | — |
| 2EVC | Crystal structure of E. COLI. methionine amino peptidase in complex with… | x-ray diffraction | A | — | — |
| 2EVM | crystal structure of methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 2EVM | Crystal structure of methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 2EVO | crystal structure of methionine amino peptidase in complex with… | x-ray diffraction | A, B | — | — |
| 2EVO | Crystal structure of methionine amino peptidase in complex with… | x-ray diffraction | A, B | — | — |
| 2GG0 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG0 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG2 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG2 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG3 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG3 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG5 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG5 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG7 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG7 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG8 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG8 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG9 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GG9 | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GGB | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GGB | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GGC | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GGC | Novel bacterial methionine aminopeptidase inhibitors | x-ray diffraction | A | — | — |
| 2GTX | Structural Basis of Catalysis by Mononuclear Methionine Aminopeptidase | x-ray diffraction | A, B | — | — |
| 2GTX | Structural basis of catalysis by mononuclear methionine aminopeptidase | x-ray diffraction | A, B | — | — |
| 2GU4 | E. coli methionine aminopeptidase in complex with NleP, 1: 0.5, di-metalated | x-ray diffraction | A, B | — | — |
| 2GU4 | E. COLI methionine aminopeptidase in complex with nlep, 1: 0.5, di- metalated | x-ray diffraction | A, B | — | — |
| 2GU5 | E. coli methionine aminopeptidase in complex with NleP, 1: 1, di-metalated | x-ray diffraction | A, B | — | — |
| 2GU5 | E. COLI methionine aminopeptidase in complex with nlep, 1: 1, di- metalated | x-ray diffraction | A, B | — | — |
| 2GU6 | E. coli methionine aminopeptidase in complex with NleP, 1: 2, di-metalated | x-ray diffraction | A, B | — | — |
| 2GU6 | E. COLI methionine aminopeptidase in complex with nlep, 1: 2, di- metalated | x-ray diffraction | A, B | — | — |
| 2GU7 | E. coli methionine aminopeptidase unliganded, 1:0.5 | x-ray diffraction | A, B | — | — |
| 2GU7 | E. COLI methionine aminopeptidase unliganded, 1:0.5 | x-ray diffraction | A, B | — | — |
| 2P98 | E. coli methionine aminopeptidase monometalated with inhibitor YE7 | x-ray diffraction | A | — | — |
| 2P98 | E. COLI methionine aminopeptidase monometalated with inhibitor YE7 | x-ray diffraction | A | — | — |
| 2P99 | E. coli methionine aminopeptidase monometalated with inhibitor YE6 | x-ray diffraction | A | — | — |
| 2P99 | E. COLI methionine aminopeptidase monometalated with inhibitor YE6 | x-ray diffraction | A | — | — |
| 2P9A | E. coli methionine aminopeptidase dimetalated with inhibitor YE6 | x-ray diffraction | A | — | — |
| 2P9A | E. COLI methionine aminopeptidase dimetalated with inhibitor YE6 | x-ray diffraction | A | — | — |
| 2Q92 | E. coli methionine aminopeptidase Mn-form with inhibitor B23 | x-ray diffraction | A | — | — |
| 2Q92 | E. COLI methionine aminopeptidase mn-form with inhibitor B23 | x-ray diffraction | A | — | — |
| 2Q93 | E. coli methionine aminopeptidase Mn-form with inhibitor B21 | x-ray diffraction | A | — | — |
| 2Q93 | E. COLI methionine aminopeptidase mn-form with inhibitor B21 | x-ray diffraction | A | — | — |
| 2Q94 | E. coli methionine aminopeptidase Mn-form with inhibitor A04 | x-ray diffraction | A | — | — |
| 2Q94 | E. COLI methionine aminopeptidase mn-form with inhibitor A04 | x-ray diffraction | A | — | — |
| 2Q95 | E. coli methionine aminopeptidase Mn-form with inhibitor A05 | x-ray diffraction | A | — | — |
| 2Q95 | E. COLI methionine aminopeptidase mn-form with inhibitor A05 | x-ray diffraction | A | — | — |
| 2Q96 | E. coli methionine aminopeptidase Mn-form with inhibitor A18 | x-ray diffraction | A | — | — |
| 2Q96 | E. COLI methionine aminopeptidase mn-form with inhibitor A18 | x-ray diffraction | A | — | — |
| 3D27 | E. coli methionine aminopeptidase with Fe inhibitor W29 | x-ray diffraction | A | — | — |
| 3D27 | E. COLI methionine aminopeptidase with fe inhibitor W29 | x-ray diffraction | A | — | — |
| 6IZ7 | E. coli methionine aminopeptidase crystal structure fitted into the cryo-EM density map of E. coli… | electron microscopy | P | — | — |
| 6IZ7 | E. COLI methionine aminopeptidase crystal structure fitted into the cryo-EM density MAP of E. COLI… | electron microscopy | P | — | — |
| 6IZI | Crystal structure of E. COLI peptide deformylase and methionine aminopeptidase fitted into the… | electron microscopy | Q | — | — |
| 6J0A | Crystal structure of E. coli methionine aminopeptidase enzyme and chaperone trigger factor fitted… | electron microscopy | P | — | 3 (best 0.44) |
| 6J0A | Crystal structure of E. COLI methionine aminopeptidase enzyme and chaperone trigger factor fitted… | electron microscopy | P | — | — |
| P0AE18 | AlphaFold monomer V2.0 prediction for methionine aminopeptidase (P0AE18) | predicted | A | — | — |
Experiment against prediction
- 2EVO chain A against the predicted model P0AE18: TM-score 1.00, RMSD 0.39 Å
- 2EVO chain A against the predicted model P0AE18: TM-score 1.00, RMSD 0.39 Å
- 2P98 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.43 Å
- 2P98 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.43 Å
- 2P99 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.44 Å
- 2P99 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.44 Å
- 2GU4 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.50 Å
- 2GU4 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.50 Å
- 2GU5 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.50 Å
- 2GU5 chain A against the predicted model P0AE18: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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