MolNFT v1 · #47555 · protein

Crystal structure of human FGF19

2P23 · Fibroblast growth factor 19: “Crystal structure of human FGF19”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #47555 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2P23
Type: protein
Length: 272 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor 19
UniProt: O95750
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fibroblast growth factor 19	protein	136	10% helix, 42% strand	O95750

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.54	0.76	33	empty

Interfaces

1 interface between chains.

A–B · 190 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2P23 · Crystal structure of human FGF19 · the same entry in another collection · chain A against A, TM-score 1.00
O95750 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 19 (O95750) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95750
Elsewhere: RCSB PDB 2P23 · PDBe 2P23 · UniProt O95750

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