MolNFT v1 · #47473 · protein
Autoinhibited intact human zap-70
2OZO · Tyrosine-protein kinase zap-70: “Autoinhibited intact human zap-70”. X-ray diffraction, 2 ligands (ANP, MG), 5 pockets (best druggability 0.79). MolNFT v1 #47473 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2OZO
- Type
- protein
- Length
- 545 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase zap-70
- EC
- 2.7.10.2
- UniProt
- P43403
- Ligands
- ANP, MG
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase zap-70 (EC 2.7.10.2) | protein | 545 | 30% helix, 20% strand | P43403 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 889 | 0.79 | 0.82 | 86 | empty |
| 2 | 145 | 0.70 | 0.89 | 25 | empty |
| 3 | 230 | 0.61 | 0.81 | 27 | MG, ANP |
| 4 | 69 | 0.38 | 0.78 | 19 | empty |
| 5 | 93 | 0.38 | 0.76 | 19 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43403
- Elsewhere: RCSB PDB 2OZO · PDBe 2OZO · UniProt P43403
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