MolNFT v1 · #47226 · protein
Solution structure of larg PDZ domain in complex with C-terminal octa- peptide of plexin B1
2OS6 · Rho guanine nucleotide exchange factor 12: “Solution structure of larg PDZ domain in complex with C-terminal octa- peptide of plexin B1”. Solution nmr, 2 pockets (best druggability 0.75). MolNFT v1 #47226 on GenesisL1: 3D structure…
- PDB
- 2OS6
- Type
- protein
- Length
- 97 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 12; C-terminal peptide of plexin-B1
- UniProt
- Q9NZN5, O43157
- Pockets
- 2 · best druggability 0.75
Structure
solution nmr · 2 distinct chains · 13% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 12 | protein | 89 | 15% helix, 35% strand | Q9NZN5 |
| B | C-terminal peptide of plexin-B1 | protein | 8 | 0% helix, 38% strand | O43157 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.75 | 0.93 | 32 | empty |
| 2 | 63 | 0.31 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 452 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2OS6 · Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZN5 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 12 (Q9NZN5) · a predicted model of the same protein · chain A against A, TM-score 0.79
- O43157 · AlphaFold monomer V2.0 prediction for plexin-B1 (O43157) · a predicted model of the same protein · chain B against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZN5
- Every structure of UniProt O43157
- Elsewhere: RCSB PDB 2OS6 · PDBe 2OS6 · UniProt Q9NZN5 · UniProt O43157
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